Malignancy disease is the II noticeable reason for death around the world. There are different kinds of tumors, for example, skin malignant growth, bosom disease, and colorectal disease. These days, treatment of malignancy is pricey. There is more noteworthy requirement for progressively productive and less harmful helpful and preventive methodologies. Phytochemicals have been utilized for the treatment of disease since the beginning because of their wellbeing, low poisonous quality, and general availability. Medicinal plants are considered as a storehouse of different bio-dynamic mixes and utilized for long time because of its helpful properties. A few plants determined mixes indicate potential job against malignancy treatment.

Background: Novel coronavirus (2019-nCov) imposed deadly health calamity with unexpected disastrous situation alarming the globe for urgent treatment regimes. World Health Organization (WHO) termed the coronavirus disease as COVID-2019 on February 11, 2020 and announced its outbreak as pandemic on 11 March 2020. The first infection was noticed in Wuhan, Hubei province, China in December 2019 and it is believed that the corona-virus is transmitted to humans through bats as a reservoir and involving human to human transfer, although the proper intermediary transmission channel is yet unestablished. Methods: Elderly populations and patients with concomitant symptoms are more at risk as compared to middle-aged patients as it may progress to pneumonia followed by severe acute respiratory syndrome (SARS) and multi-organ failure. Morbidity rates estimated in patients are less i.e. 2-3% but the dearth of a specific treatment strategy to prevent coronavirus infection is a major concern. Results: Currently, anti-viral and anti-malarial drugs are in practice for the management of COVID-19 disease along with plasma therapy in the absence of a potent vaccine. Besides, home isolation and social distancing are the precautionary measures adopted by many countries to minimize the spread of infection. Various studies have been conducted and numerous are still going on to establish specific treatment for COVID-19. Conclusion: In this review, we summarized information on the structural components of COVID19 virus with special emphasis on virus genome, life cycle, the importance of protease enzyme, the role of spike proteins in viral replication, validated drug targets, ongoing effective treatments for COVID-19 management and the latest research on drug design to develop anti-CoV drugs.

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