No abstract

A median weekly dose of etelcalcetide was 15 mg (7.5-22.5 mg) and did not differ between naïve patients or switched from cinacalcet.After the switch of treatment, none of the patients developed clinical intolerance or new adverse effects. Etelcalcetide was more effective than cinacalcet in controlling secondary hyperparathyroidism. The dose conversion factor for the switch was [etelcalcetide/week] ¼ 0.277Â[mg cinacalcet/day], indicating that single dose of etelcalcetide (2.5 mg per session) is functionally slightly less than single dose of cinacalcet (30 mg per day). Conclusions: These results indicate that the signs of assumed autonomous parathyroid glands adenoma could predict therapeutic response of etelcalcetide better than PTH level.

Irritable bowel syndrome (IBS) is diagnosed in 8−17% of the general population and it is one of the most often problem seen in gastroenterology. Literature dates showed that in 54 to 100% IBS patients some psychiatric illness or disorder was diagnosed. This transversal hospital based study was realised in order to evaluate the levels of anxiety and depression, as well as to assess personality traits, neuroticism and neurotic characteristic of personality of pain predominant IBS patients and to compare obtained results with the same among healthy individuals. Methods: Standard psychometric instruments employed included the Hamilton anxiety and Hamilton depression scale, Minnesota Multiphasic Personality Inventory (MMPI) and Eysenck Personality Inventory (EPI). Results: High anxiety scores were noted among 14% IBS patients and none of healthy individuals noted such high scores from 21 to 25. The similar trends were observed in depression levels and 10% IBS patients had depression scores over 15, while such high scores were not reported in control group. Most of IBS patients had prominent neuroticism observed using Eysenck Personality Inventory, as well as high scores on hypersensitivity, depression and hysteria neurotic scales of MMPI. Conclusions: Our study showed that the patients suffering from IBS and seeking medical help because of their symptoms, reported many emotional problems among which anxiety and depression are the most prominent. It can be concluded that patients with IBS have premorbid personality characteristics that modulate the way that perceive and become distressed by physiological causes, resulting in depression, anxiety symptoms and more health-care-seeking behaviour.

Effects of prostaglandin E₂ (PGE₂) and cholinergic drugs on intraocular pressure (IOP) have been studied in the rabbit. PGE₂ injected intracamerally in a dose of 5 µg produced a long-lasting increase in IOP. Topical pretreatment with carbachol, physostigmine and pilo-carpine abolished the rise of IOP after the intracameral injection of PGE₂. When the IOP had already been increased by PGE₂ topical application of pilocarpine and physostigmine did not change it. Carbachol even potentiated the pressor effect of PGE₂.