The aim of the research is to study the parameters of tolerance and adherence to antihypertensive therapy in patients with arterial hypertension and comorbidity in real clinical practice. Material and methods. The study included 138 adult patients (29% of men and 71% of women) with arterial hypertension and comorbidity receiving therapy in the cardiology department. The average age of the patients was 64.3 ± 12 years. Results. The mean Charlson index in our study was 3.97 ± 2.0 points (3.75 ± 2.3 points for men and 4 ± 1.9 points for women). Treatment adherence was low in 40% of men and 24.5% of women. The lowest rates of adherence were found to medical follow-up (85% in men and 83.6% in women) and lifestyle modifications (80% in men and 77.5% in women), the highest rates of adherence were to drug therapy (20 % for men and 18.4% for women). Significant correlations were found for all adherence categories with age and the number of drugs taken.Conclusion. Adherence to treatment in almost a third of the patients we surveyed was low. The lowest rates of adherence were found to medical support and lifestyle modifications, the highest were found to drug therapy. The factors influencing adherence, efficacy and tolerability of treatment includes age and the number of drugs taken.

The effect of antihypertensive and hypolipidemic therapy with the use of a fixed combination of amlodipine, lisinopril and rosuvastatin on the parameters of cytokines (the level of the proinflammatory cytokine - interleukin-1β, anti-inflammatory cytokine - interleukin-10, ligand CD40 (CD40L)), central aortic pressure, arterial stiffness and the value of albuminuria in patients with stage 3 chronic kidney disease, both in combination with arterial hypertension (AH) of 1-2 degrees, and without it, and in patients with coronary artery disease in combination with AH. The results of the study allow to conclude that the proposed antihypertensive and hypolipidemic therapy significantly reduces the parameters of central hemodynamics and vascular stiffness, the levels of microalbuminuria (MAU) and blood creatinine in patients with stage 3 chronic kidney disease in combination with AH of 1-2 degrees, and significantly increases the values IL-10 in patients with hypertension and CKD.

Purpose. The work is devoted to study the effects of antihypertensive, lipid-lowering and metabolic therapy in office and the average hemodynamic parameters, the parameters of central pressure in the aorta, vascular wall stiffness and quality of life in patients with CKD stage 3 in combination with arterial hypertension of 1-2 degrees, and without it. Materials and methods. Were examined patients with arterial hypertension of 1-2 degrees and CKD stage 3. Measured hemodynamic parameters with the help of a daily BP monitor “BPLab”. The quality of life of patients was assessed by the questionnaire MOS SF36. Results. The greatest changes in the indicators of central hemodynamics and vascular stiffness were noted in the group of patients with comorbidity. Conclusion. The combination of antihypertensive therapy (losartan and diltiazem) with meldonium and rosuvastatin significantly decreases indices of central and peripheral hemodynamics and vascular stiffness. Add meldonium part of therapy significantly improves the quality of life of patients.