A novel Brønsted acidic ionic liquid 2-ethyl imidazolium hydrogen sulfate, [2-Eim] HSO4, was synthesized. Its structure was investigated using FT-IR, 1 H NMR, 13 C NMR, UV, TGA and DTA spectra. This ionic liquid is utilized as a highly efficient and homogeneous catalyst for the promotion of hexahydroquinolines via one-pot multi-component condensation of aromatic aldehydes, dimedone, ethyl acetoacetate, and ammonium acetate at room temperature and neat conditions. Also, optimization of the reaction conditions was investigated using the response surface method {Central Composite Design (CCD)}. This new method consistently has the advantages of excellent yields and short reaction times. Further, the catalyst could be reused and recovered at least four times without appreciable loss of activity.
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