Key Points Mutant CALR induces TPO-independent growth in the human megakaryocytic cell line UT-7/TPO. Mutant CALR binds to the TPO receptor, inducing phosphorylation of JAK2 and activating downstream signaling.

BCR-ABL+lineage−c-kit− immature leukemia cells produce inflammatory MIP-1α/CCL3 to maintain leukemia-initiating cells and promote development of chronic myeloid leukemia.

No abstract

Key Points Basophil-like leukemia cells crucially contribute to CML development by providing an inflammatory chemokine, CCL3.

SummaryOverexpression of high mobility group AT-hook 2 (Hmga2), which is negatively regulated by MIRLET7 micro RNAs through 3 0 -untranslated region