No abstract

To determine the effect of a reduced radiotherapy dose on short-and long-term swallowing problems after organ-sparing treatment. Design: Prospective case series. Setting: Tertiary care referral center. Patients: A consecutive sample of 29 patients with advanced oropharyngeal or hypopharyngeal cancer who were treated with intravenous hydroxyurea and concomitant hyperfractionated, accelerated radiotherapy. Interventions: Initial experience with 74.4 Gy of radiation demonstrated severe long-term swallowing problems, prompting a dose reduction to 60.0 Gy. Eighteen patients were followed up for this study in the 74.4-Gy group, while 11 were in the 60.0-Gy group. Main Outcome Measures: Swallowing variables were assessed in both patient groups at 4 months and at 12 months following completion of therapy. Results: Patient demographics and tumor characteristics were similar in each group, while significant differences were noted in the posttreatment clinical swallowing variables. Persistent severe odynophagia at 4 months (89% [16/18] vs 30% [3/10]) and at 12 months (64% [7/11] vs 11% [1/9]) was greater in the 74.4-Gy group (P=.002). Clinical signs of aspiration were also increased in the 74.4-Gy group, with 81% (13/16) vs 11% (1/9) at 4 months and 60% (6/10) vs 11% (1/9) at 12 months (PϽ.05). Most striking, however, was the incidence of long-term gastrostomy, with 78% (14/18) of patients receiving 74.4 Gy requiring gastrostomy feedings at 12 months compared with 18% (2/11) in the 60.0-Gy group (P=.002). Local control was unchanged by the altered dosing, with median followups of 43.5 and 24.0 months in the 74.4-Gy and 60.0-Gy groups, respectively. Conclusion: Decreased radiation doses can maintain disease control and reduce treatment-related long-term swallowing complications.