The most prevalent infectious cause of blindness is trachoma. Trachoma is the third most common cause of low vision and the second most common cause of blindness in Ethiopia. It is more common in regions where personal and community cleanliness standards are inadequate. This review's objectives are to explore trachoma epidemiology and look at trachoma preventive and control initiatives in Ethiopia. Document review and Pub-med searches were made based on the search items: trachoma, epidemiology of trachoma worldwide and in Ethiopia, and prevention and control program of trachoma in Ethiopia. Trachoma prevalence declined from an average of 26.6% in 2015 to 13.3% in 2020 in Ethiopia, and Trachomatous trichiasis prevalence among those under the age of 15 decreased from 4% to 0.85%. Trachoma continues to be a serious public health issue in the nation despite the persistent efforts that were successful in ending the issue.