Present study was conducted to compare the effects of adding clonidine vs dexmedetomidine to lignocaine in Bier`s block. It was prospective randomised double-blinded. 40 patients of ASA I or II posted for upper limb surgery under Bier`s block were included. Bier`s block was given with lignocaine with either dexmedetomidine 1μg/kg or clonidine 1μg/kg. There was no significant difference between the two groups in onset or regression of sensory and motor blockades. There was a significant decrease in number of patients requiring analgesia and its consumed amount in the Dexmedetomidine group (0% and 0μg, respectively) as compared to the Clonidine group (40% and 27±43μg, respectively) intraoperatively. There was a decrease in number of patients requiring analgesia and its consumed amount in Dexmedetomidine group (5% and 2.5±11μg, respectively) compared to the Clonidine group (35% and 32±24.5μg, respectively) post-operatively. The quality of anaesthesia was significantly better in Dexmedetomidine group than to Clonidine group. Patients were more sedated in the Dexmedetomidine group for brief post-operative period. This study concludes, adding dexmedetomidine to lignocaine in Bier`s block is more beneficial than adding clonidine.

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