Aim: The aim this research work is to formulate and characterize Poly Sulfoxyamine Grafted Chitosan Coated contact Lens. Methodology: Poly Sulfoxyamine Grafted Chitosan was used for coating the Lens & converting it in to Antimicrobial Lenses. Poly Sulfoxyamine Grafted Chitosan was performed in the presence of pyridine and further treatment with ammonia during reaction of Thionyl chloride & chitosan. The UV light interference, visible light transmission and antimicrobial evaluation were studied. Results: The results indicate that Contact lenses prepared with Modified Poly Sulfoxyamine Grafted Chitosan absorbed some UV radiation & does not interfere with visible region. Due to the antimicrobial activity of modified Chitosan, the growth and transmission of micro organisms are reduces in coated Lens as compared to uncoated Lens. Conclusion: On basis of the results we concluded that Modified Poly Sulfoxyamine Grafted Chitosan might be used as coating material or material for making contact Lenses which will be less susceptible for microbial contamination.