No abstract

Objective: Lacosamide is an antiseizure agent and most commonly prescribed drugs for epilepsy. The aim of this work was evaluating the effect of Lacosamide (at its therapeutic range) on the kidney of pregnant albino rats.Methods: Forty pregnant rats were divided into two groups, group I received 1.5 ml/day distilled water in two divided doses throughout pregnancy. Rats in the group II received 1.5 ml/day distilled water (containing 36 mg Lacosamide) two divided doses. At the end of the experiment, blood samples were collected, and the sera were separated and used for biochemical analysis. The Kidneys were excised and examined by light and electron microscopic.Results: Treatment with Lacosamide induced undesirable histopathological changes in the kidney. These changes were in the form of fusion and effacement of secondary foot processes, thickening and disruption of the glomerular basement membrane, widening of the Bowman's spaces, cytoplasmic vacuolation, and swollen mitochondria with loss of their cristae. Such changes were confirmed by alteration of some biochemical parameters of kidney functions.Significance: Authors concluded that Lacosamide induced adverse effects on the kidney of pregnant albino rats. Further investigations are needed to identify the mechanism of Lacosamide toxicity.