Ozone is a form of oxygen which has shown to be fruitful in the management of various diseases for many years now. Ozone therapy is slowly emerging as an alternative treatment modality for many dental pathologies catering to all age groups. It has proven to be beneficial than conventional strategies with applications to dental treatment. The present article aims to discuss the role of ozone in the management of certain conditions in the oral cavity and its possible clinical applications in the future.

An open apex in a nonvital permanent tooth makes endodontic treatment a challenge. There is a necessity to induce or create an apical barrier against which the obturating material can be compacted. The present article reports the effective closure of root apex in a pulpless permanent upper incisor tooth with wide-open apex utilizing Biodentine in blend with platelet-rich fibrin in the form of a matrix showing excellent healing potential at a 12-month follow-up.