The title compound, [Ni2(C12H12N2O4S3)(H2O)4]·2C3H7NO·3H2O, is made up of a centrosymmetric, bimetallic complex containing a 24-membered macrocyclic ring, two dimethyl­formamide and three water solvent mol­ecules. The Ni atom adopts a slightly distorted NiO6 octahedral geometry arising from two O,O-bidentate ligands and two water molecules. There are inter­molecular O—H⋯O and O—H⋯N inter­actions in the crystal structure. One of the uncoordinated water molecules is diordered over two sets of sites of equal occupancy.