Leishmania parasites are the etiological agents of Leishmaniasis, a tropical disease that affects around 15 million people in about 90 countries. The chosen therapy for this disease is based on antimony V compounds, such as meglumine antimoniate. It can be administered as a parenteral, subcutaneous or perilesional form as successive infiltrations with pre-established doses localized in the border of the granuloma that characterizes the wound of Cutaneous Leishmaniasis (CL). Herein, a topical pharmaceutical recipe, such as an emulsion, is proposed to eliminate the trauma caused by administering the medicine in parenteral form to the face or other difficult access zones. The evaluation of this vehicle was performed by analyzing parameters such as pH, viscosity, homogeneity and droplet size distribution. Furthermore, the effectiveness of the emulsion was proved by in vitro experiments using Strat-M synthetic membranes, showing that the transdermal passage of the antimonial complex is guaranteed. Moreover, complete healing of the wound has been attained in patients with CL, as shown with two clinical cases in this article.

The essential oil of Aniba hostmanniana (Nees) Mez, family Lauraceae, was obtained from fresh leaves by hydrodistillation. The chemical composition of the oil was assessed using gas chromatography with mass spectrometric detection (GC-MS). The antimicrobial activity of the essential oil was tested against Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia) and the Gram-positive bacterium Staphylococcus aureus. GC-MS analysis revealed the presence of 35 compounds in the essential oil, the predominant ones being benzyl benzoate (29.3%), δ-cadinene (12%), β-caryophyllene (10.5%), bicyclogermacrene (5.9%), and α-copaene (3.9%). The oil showed activity against most of the bacterial strains studied.

A new prenylated benzoic acid derivative, named myrsicorianol (1), was isolated from the fruits of Myrsine coriacea and its structure was determined by spectral analysis, including 1D-and 2D-NMR experiments. Myrsinoic acid A and a mixture of the p-benzoquinones, embelin, rapanone and 2,5-dihydroxy-3-pentadecyl-1,4-benzoquinone (homorapanone) were also obtained from the fruits, whilst the bark afforded myrsinoic acid A, myrsinoic acid B, 3-(3',7'-dimethyl-2',6'-octadienyl)-4hydroxybenzoic acid and 3-(3',7'-dimethyl-2',6'-octadienyl)-4-methoxybenzoic acid.

The quantitative and qualitative chemical composition of a benzene extract from