Objective : Lycii Fructus Extracts(LFE) can do Anti-hypertension activity, Antidepressant, Anti-diabetic activity. This study was designed to investigate effects of LFE on skin whitening and elasticity using melanoma cells. Methods : In this experiment, effect of LFE on cell viability, inhibition of melanin synthesis and inhibitory effect on tyrosinase and elastase. Results : More than 250 ㎍/㎖ of LFE treated group showed lowered proliferation rates significantly compared to non-treated group. More than 125 ㎍/㎖ of LFE treated groups were lower levels of melanin synthesis respectively. LFE showed inhibitory effect on tyrosinase activities in vitro. And, LFE suppressed tyrosinase activities in B16F10 cells significantly. Finally, LFE suppressed elastase type Ⅰ and Ⅳ activities in dose-dependent manner in vitro. And LFE also slightly suppressed elastase activities in vivo. Conclusion : These results suggest that LFE can inhibit melanin synthesis through ihhibitory action on tyrosinase activity and inhibt elastase activity, and also suggest that these results can be used for the study on maintaining skin elasticity or whitening.

Objectives : This is a clinical report on a 63-year-old female patient with Trigeminal Neuralgia (TN) treated by oriental medicine treatments.Methods : The patient was treated by acupuncture, moxibustion and herb medication. The improvement of the patient was judged by Visual Analog Scale(VAS).Results : The pain had been gradually reduced and VAS became 2 after the treatment for 25 days. Conclusions : Oriental medicine treatment including Bogigeopung-san was very effective to improve the TN patient's symptoms. It is necessary to have more observations and cases on the patients with TN.