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Background: An Uncontrolled Novel COVID-19 started from Wuhan city of China in Late 2019 and spread worldwide has called for unprecedented measures, to prevent it Pakistan government Imposed lockdown on the entire country. Lockdown has a huge impact and affected on mental health of population. The present study aims to assess the effect of COVID-19 on mental health of population and identify the coping strategies to overcome this mental health issues caused by pandemic. Methods: An online survey was administered from 26 May-14 June 2020 to 398 participants. Post Hoc test was performed to examine the associations between general health questionnaire GHQ-12 and socio-economic variables. Results: Losing jobs due to pandemic and lockdown situation and using negative coping strategies were the factors associated with psychological disorders.This study shows high rates of anxiety and stress in younger population specifically in young women with higher odds of endorsing a worst mental health outcome. Outcomes were associated with a number of COVID-19 related risk factors such as challenging family relations, loss of job, no physical activity, financial burden, experiencing stress full events and suicidal ideation. Conclusion: The present situation requires awareness in public media which could be helpful to deal with this and this present article provides details of COVID-19 pandemic situation on mental health of younger population.

Background: Bronchial asthma is the leading respiratory disease among all chronic inflammatory conditions. Due to various causative factors, it's incidence has been drastically increased over last decades. Despite the availability of potent anti inflammatory & bronchodilator therapies, there is a need to find new pharmacological molecules possessing targeted mechanism and lesser side effects towards it's pathogenesis. In this study, Uncaria tomentosa belonging to family Rubiacae was selected to evaluate anti asthmatic effect owing to it's specific anti inflammatory properties. Aim: To evaluate the effectiveness of uncaria tomentosa leaves on respiratory smooth muscles in case of bronchospasm and constriction. Study Design: Experimental comparative type Place and Duration of Research: University of health sciences. Duration of study is 1 year Methodology: Ethanolic extract of Uncaria tomentosa leaves was prepared according to the protocol. We took 24 male mice and divided them equally in groups of four. These groups represented control, diseased, UT (Uncaria tomentosa) leaves and MP (Methylprednisolone) treated. Bronchial asthma was induced by Ova sensitization on day 0 and OVA challenge on day 14 followed by treatment with UT leaves extract (200µg/animal/day) and MP (15mg/kg b.w) for next 7 days. Animals were sacrificed and lungs were removed to check histopathological findings. Results: The animals belonging to diseased group showed all histopathological features suggestive of bronchial asthma as compared to control group. Inflammatory score, epithelial cell hyperplasia and vascular congestion was found to be significantly decreased in both treatment groups. Conclusion: UT leave extract may possess anti asthmatic activity comparable to Methylprednisolone. Keywords: Phosphate Buffer Saline PBS, Tumor necrosis factor alpha TNF-α, Methylprednisolone MP, Uncaria tomentosa UT