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Objective-To document the trend in arterial hypoxaemia and electrocardiographic abnormalities on the second to sixth nights after acute myocardial infarction. Patients-Nineteen consecutive patients with acute myocardial infarction who were monitored continuously during the night (minimum 2300-0700) with a Holter tape recorder and a pulse oximeter. Fifteen patients were monitored for five nights, one patient for four nights, one patient for three nights, and two patients for two nights. Results-Five patients had >30 episodic oxygen desaturations of > 5% during the nights of monitoring and many patients had episodes with oxygen desaturations to <80% ranging from 46% to 61% (from 7/15 to 11118 patients) during the nights of monitoring. Constant hypoxaemia was found in 11-13% (2115)

Treatment of patients with congestive heart failure with the angiotensin-converting enzyme inhibitor, fosinopril, reduce the elevated plasma endothelin level to normal values. The relation between plasma endothelin and clinical parameters indicates that endothelin may play a pathophysiological role in the progression of congestive heart failure.

Objective-To re-examine the prevailing hypothesis that women fare worse than men after acute myocardial infarction.

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