A series of novel ninhydrin-derived spiro-quinazolinone derivatives in moderate to good yields have been synthesised through a ferric chloride catalysed reaction in 1,2-dichloroethane.

A Highly Efficient Method for the Synthesis of Novel 1'H-Spiro[indene-2,2'-quinazoline]-1,3,4'(3'H)-trione Derivatives. -The title compounds are prepared by reaction of ninhydrin with aminobenzamides in moderate to good yields using ferric chloride as catalyst. -(SADAT-EBRAHIMI, S. E.; IRANNEZHAD, S.; MOGHIMI, S.; YAHYA-MEYMANDI, A.; MAHDAVI, M.; SHAFIEE, A.; FOROUMADI*, A.; J. Chem. Res. 39 (2015) 9, 495-498, http://dx.doi.org/10.3184/174751915X14394002808669 ; Dep. Med. Chem., Fac. Pharm., Tehran Univ. Med. Sci., Tehran, Iran; Eng.) -B. Mosebach 15-105