working and living environments supporting active and healthy ageing.ABSTRACT A steady rise has been observed in the percentage of elderly people who want and are still able to contribute to society. Therefore, early retirement or exit from the labour market, due to healthrelated issues, poses a significant problem. Nowadays, thanks to technological advances and various data from different populations, the risk factors investigation and health issues screening are moving towards automation. In the context of this work, a worker-centric, IoT enabled unobtrusive users health, wellbeing and functional ability monitoring framework, empowered with AI tools, is proposed. Diabetes is a high-prevalence chronic condition with harmful consequences for the quality of life and high mortality rate for people worldwide, in both developed and developing countries. Hence, its severe impact on humans' life, e.g., personal, social, working, can be considerably reduced if early detection is possible, but most research works in this field fail to provide a more personalized approach both in the modeling and prediction process. In this direction, our designed system concerns diabetes risk prediction in which specific components of the Knowledge Discovery in Database (KDD) process are applied, evaluated and incorporated. Specifically, dataset creation, features selection and classification, using different Supervised Machine Learning (ML) models are considered. The ensemble WeightedVotingLRRFs ML model is proposed to improve the prediction of diabetes, scoring an Area Under the ROC Curve (AUC) of 0.884. Concerning the weighted voting, the optimal weights are estimated by their corresponding Sensitivity and AUC of the ML model based on a bi-objective genetic algorithm. Also, a comparative study is presented among the Finnish Diabetes Risk Score (FINDRISC) and Leicester risk score systems and several ML models, using inductive and transductive learning. The experiments were conducted using data extracted from the English Longitudinal Study of Ageing (ELSA) database.INDEX TERMS T2DM, long-term health risk prediction, machine learning, ensemble learning

Although machine learning (ML) has shown promise across disciplines, out-of-sample generalizability is concerning. This is currently addressed by sharing multi-site data, but such centralization is challenging/infeasible to scale due to various limitations. Federated ML (FL) provides an alternative paradigm for accurate and generalizable ML, by only sharing numerical model updates. Here we present the largest FL study to-date, involving data from 71 sites across 6 continents, to generate an automatic tumor boundary detector for the rare disease of glioblastoma, reporting the largest such dataset in the literature (n = 6, 314). We demonstrate a 33% delineation improvement for the surgically targetable tumor, and 23% for the complete tumor extent, over a publicly trained model. We anticipate our study to: 1) enable more healthcare studies informed by large diverse data, ensuring meaningful results for rare diseases and underrepresented populations, 2) facilitate further analyses for glioblastoma by releasing our consensus model, and 3) demonstrate the FL effectiveness at such scale and task-complexity as a paradigm shift for multi-site collaborations, alleviating the need for data-sharing.

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