A medicinal plant is one that can be used for traditional and therapeutic uses and is also a precursor for the synthesis of life saving drugs. Calotropisgigantea, Calotropis procera and Calotropis acia are some such plants. Calotropis gigantea, Calotropis procera and Calotropis acia belongs to the Asclepiadaceae family.The geographical distribution of Calotropis gigantea, Calotropis procera, and Calotropis aciahave been seen in several places throughout Asia.This review elaborates on the phytochemical composition and bioactive compounds and their therapeutic uses present in these plants. The vegetativeand floral characteristics of Calatropisgigantea, Calotropis procera and Calotropis acia have been differentiated for better understanding of these unique plants. The medicinal and pharmacological applications of Calotropis gigantea, Calotropis proceraand Calotropis aciahave been illustrated.