Hospitalization is a crisis situation for children, when they are sick and treated in the hospital, they must adapt to the hospital environment. Based on the latest data from WHO in 2015, around 77,423 children worldwide experience several problems due to hospitalization. The purpose of this research was to determine the relationship between hospitalization stress and changes in sleep patterns in children aged 3-6 years at Haji Hospital, Makassar. The type of research is an analytic observational with a cross-sectional approach. The population was hospitalized children aged 3-6 years in the Al-Fajar Room/Child Care Room at Haji Hospital of Makassar, and the sample size was 45 children using accidental sampling. Data collection used observation sheets and analyzed using the Chi-Square test. The results showed that from 30 respondents experienced hospitalization stress, 16.7% did not experience a change in sleep patterns, and 83.3% experienced changes in sleep patterns. While the respondents who did not experience hospitalization stress were 15 respondents, where 53.3% did not experience changes in sleep patterns, and 46.7% experienced changes in sleep patterns.