Objectives: This review provides a detailed review of the treatment of obesity with natural products that are formulated as phytosomes. When novel drug delivery technology is used instead of traditional drug delivery in herbal medicine, side effects are reduced while safety and efficacy are improved.This article provides information about obesity along with its treatment and with special emphasis on phytosomes, their preparation and evaluation along with their application in obesity. Methods: A comprehensive search of electronic databases such as Medline, Embase, Cochrane Library, Google, and Google Patents was carried out. Results: This review explains the details of research done on phytosomes with special reference to anti-obesity drugs. Still, there is a need to formulate anti-obesity herbal drugs as phytosomes to get better bioavailability, and fewer side effects. This phytosomal drug delivery approach may resolve the problems associated with conventional drug delivery. Conclusion: Integrating herbal medicine with novel drug delivery systems such as phytosomes to combat obesity has a significant scope and importance.

Nature contains a diverse range of phytoconstituents that possess several pharmacological properties. However, the effectiveness of herbal formulations is limited due to the poor bioavailability of phytoconstituents, which makes it difficult for them to pass through the cell membrane. Phytosomes are a modern type of herbal formulation that comprises therapeutically active phytoconstituents extracted from medicinal plants and enclosed by phospholipids. By combining phytoconstituents with phospholipids, phytosomes are able to enhance bioavailability and reduce side effects. Various techniques such as solvent evaporation, rotatory evaporation, anti-solvent precipitation, freeze-drying, and solvent ether injection can be used to prepare phytosomes. Phytosomes can be evaluated using methods such as UV-Spectra, DSC, drug entrapment and loading capacity, surface tension activity measurement, and in-vitro/in-vivo studies. This review discusses different methods for preparing phytosomal formulations and their advantages, which have been found to significantly improve the bioavailability of phytoconstituents. Phytosomes have high entrapment efficiency and do not compromise the safety of nutrients. By utilizing phytosomal drug delivery, issues associated with conventional drug delivery may be overcome. Therefore, it is important to combine Indian Ayurvedic medicine with novel drug delivery systems to improve drug delivery technologies