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BACKGROUND: To identify the impaired organ dysfunction and study the relevance of SIRS in predicting the organ dysfunction among 100 patients who fullled the criteria for SIRS AIM:1. To identify the organ dysfunction among patients with systemic inammatory response syndrome (SIRS). 2. To study the relevance of systemic inammatory response syndrome predicting an impaired organ function. MATERIALS AND METHODS: A six-month hospital-based prospective study was conducted in General Medicine, Santhiram Medical College, and General Hospital after approval from the Hospital Ethics and Research Committee. The study population consisted of patients admitted to this hospital who met the inclusion criteria. The clinical and laboratory proles of fty of these patients were examined. RESULTS: 35% of the patients belonged to the 36-55 age group, and 33% belonged to the 56-75 age group. The respiratory system was the most common site for the focus of infection leading to systemic inammatory response syndrome (SIRS). (40%). Our study's most common organ dysfunction was the renal system (39%), followed by the respiratory system (32%). Single organ dysfunction was commonly observed (36.4%), followed by 2 & 3 organ dysfunctions in 21.8%. 4 and 5 organ dysfunctions were observed in 10.9% and 9.1% of patients, respectively. The average number of days of hospital stay of the patients was 6-10 days, and the mortality was 21% in our study. The increase in the age of patients was associated with higher mortality in our study. Patients with SIRS criteria 2 had minimal organ dysfunction, whereas SIRS criteria 4 had the maximum number of organ dysfunctions. CONCLUSION:Thosepatientswithanincrease inSIRScriteriahadhigherimpairedorganfunctions andhighermortality.Hence thedocumentationof SIRScriteriainacutelyillpatientsisofparamountimportanceasithelpspredicttheorgandysfunctionsandtheoutcomeofthepatients.