BACKGROUNDThe safety profile of anti-epileptic drugs (AEDs) is an essential consideration for the regulatory bodies, owners and prescribing clinicians. Meta-analysis has increasingly been used to identify adverse effects of drugs. Efficacy studies are often too small to reliably assess risks that become important when a medication is in widespread use, so meta-analysis, which is a statistically efficient way to pool evidence from similar studies, seems like a natural approach. The safety profile of drugs is an important consideration, and it affects clinicians' decisions to prescribe specific AED(s), as serious adverse effects can lead to chronic complications or even death. Less serious, but significant, adverse effects can significantly impact quality of life, leading to systematic illness which may increase the overall cost of treatment. METHODS An electronic search was performed in using Pubmed,Paediatric journals of Neurology, MEDLINE. RESULTS The literature search identified 30 unduplicated papers. Of these 11 papers were excluded by reading the abstracts and titles. Another ten papers were excluded from reading their complete text. We selected nine papers which comprised of case studies and observational studies. CONCLUSION The combination of different antiepileptic drugs has resulted in drug-induced choreoathetosis. A mainly increased risk was seen with combinations that have phenytoin and lamotrigine. This could be due to an additive or a synergistic effect on central dopaminergic pathways.

Background: Wilson's disease is a rare autosomal recessive disorder characterised by the accumulation of copper in the liver, brain, cornea and kidneys. This is a hospital-based study; there are no community-based prevalence and incidence studies of Wilson's disease in India. Case Summary: An eleven-year-old female girl was presented to the paediatric department with significant complaints of yellowish discolouration of eyes, high coloured urine, fever, swelling of feet and abdominal distention. Using the elevated levels of ceruloplasmin, urine copper and the presence of KF rings on both eyes Wilson's disease with decompensated cirrhosis was confirmed. She was treated with copper chelators (D-penicillamine & Zinc) and antioxidants. Gradually she showed improvement in clinical signs and LFT. Conclusion: Wilson's disease is an inherited metabolic disorder. Early diagnosis and appropriate management help to prevent the systemic complications. Siblings needed to be screened to prevent manifestations. It also points out the need to suspect Wilson's disease in any young patient presented with the unexplained liver disease.

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