Telavancin is a bactericidal, semisynthetic lipoglycopeptide indicated in the UnitedThe vanA operon encodes a dehydrogenase, VanH, which reduces pyruvate to D-Lac (7); a ligase, VanA, required for the synthesis of D-Ala-D-Lac (7); and a D,D-dipeptidase, VanX, that hydrolyzes D-Ala-D-Ala, preventing its incorporation into cell wall precursor molecules (21) (Fig.

TD-1792 is a new multivalent glycopeptide-cephalosporin antibiotic with potent activity against Gram-positive bacteria. The in vitro activity of TD-1792 was tested against 527 Staphylococcus aureus isolates, including multidrug-resistant isolates. TD-1792 was highly active against methicillin-susceptible S. aureus (MIC 90 , 0.015 g/ml), methicillin-resistant S. aureus, and heterogeneous vancomycin-intermediate S. aureus (MIC 90 , 0.03 g/ml). Time-kill studies demonstrated the potent bactericidal activity of TD-1792 at concentrations of <0.12 g/ml. A postantibiotic effect of >2 h was observed after exposure to TD-1792.

These in vitro and pre-clinical in vivo studies demonstrate that telavancin has the potential to be efficacious in infections caused by hVISA.

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Current MRSA decolonisation regimens are well tolerated and effective for MSSA decolonization for the anterior nares and groin. The decolonization effect is preserved for at least 10 days following treatment.