Nowadays NSAIDs are the most frequently used groups of drugs, especially because of their availability. Their consumption is high among older people, who are much more sensitive to the side effects, and who are often also taking other drugs which can interact with them. Moreover, the majority of the older population is suffering from hypertension. This could well explain the commonly encountered experience of drug interaction between NSAIDs and antihypertensive drugs, which is very common in clinical practice. The severity of this drug interaction is classified as class C, with a recommendation to monitor therapy. However, even a minor long-term increase in blood pressure can significantly increase the risk of cardiovascular mortality, while mortality rates can possibly be reduced by sufficiently effective treatment of hypertension. Therefore, in clinical practice, this type of interaction should not be overlooked as a major cause of failure of hypertension treatment in older patients, as well in many cases in general. The present article focusses on the mechanism and the degree of influence on the blood pressure of particular types of antihypertensive agents used in combination with NSAID. Not all groups of antihypertensive drugs are affected to the same degree; some are more affected, and others, such as calcium channel blockers, are not affected at all. Similarly, not every NSAID increases blood pressure. Many studies, some of which are analyzed in this article, present evidence of the degree of the influence NSAIDs have on blood pressure (Adv Clin Exp Med 2014, 23, 6, 993-1000). Hypertension is well known as one of the most common cardiovascular diseases. Approximately 690 m people around the world suffer from hypertension. It is one of the major risk factors causing arteriosclerosis, including atherogenic coronary artery disease in the form of ischemic heart disease [1]. Hypertension affects the majority of people over 65 years of age, occurring in up to 60% of this population [2]. In most cases, it accounts for subsequent organ damage or many other manifestations of cardiovascular diseases [2,3]. Adequate treatment of hypertension is important especially in older populations, as has been confirmed by the HYVET study [4]. Moreover, older populations often experience pain, both chronic and acute. The use of different analgesics therefore becomes a regular part of their lives. It should therefore be borne in mind that the treatment of hypertension may be significantly influenced by the concomitant use of other therapeutic classes.The authors of this article focused on clarifying the mechanisms of the influence on blood