Wells in the Vaca Muerta field have consistently hosted an array of technical challenges from downhole conditions in the extended lateral section, including casing collapse or restrictions developed during the hydraulic fracturing phase. With these factors in mind, an initiative was made to implement key operational parameters to improve efficiency during Coiled Tubing (CT) operations without sacrificing (Health, Safety, and Environment) HSE or (Service Quality) SQ during the completion life cycle associated with unconventional activities. Operational optimizations based on ongoing diagnostic, design and delivery of CT well interventions are shown in this paper through a chronological compilation of 45 wells in 12 pads. Initially, CT milling job times were defined based on the minimum and maximum speeds while running in and pulling out of the hole, circulation fluid parameters to ensure turbulent flow and parameters for gel sweeps and wiper trips. Subsequently, a series of reviews of the data collected from operations was implemented, and the focus was shifted to operating times at the different job stages. This was followed by stream mapping the personnel and equipment assigned to each specific activity. Additionally, Key Performance Indicators (KPIs) were defined, such as CT speed between the surface and the kick-off point, average speed between plugs, plug milling time, and time to return to surface while pulling out of the hole. This journey to efficiency has been achieved by systematically introducing continuous improvements into our operations, utilizing on-site field personnel as the main driver and the engineering team as support, monitoring the execution, and taking action when needed. After servicing 45 wells across 12 locations over two years, an 11% reduction of the total time in the well during frac plug mill out has been achieved. Considering that the lateral length of the wells and the number of stages has increased by 52% and 41%, respectively, this has enabled significant cost savings in a safe and effective way. Operational efficiency has to be aligned with contemporary advances in the industry. As completion strategies evolve, so must our intervention methods. This paper documents how the completion life cycle of wells in a challenging, unconventional environment has been reduced through customized well interventions with CT.