Herein we report the rational design of new phosphopeptides for control of nucleation, growth and aggregation of water-soluble, superparamagnetic iron-iron oxide core-shell nanoparticles. The use of the designed peptides enables a one-pot synthesis that avoids utilizing unstable or toxic iron precursors, organic solvents, and the need for exchange of capping agent after synthesis of the NPs.

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The rational design of a capping peptide for the synthesis of various noble metal nanoparticles is presented. The peptide contains nonnatural, phosphonated amino acids introduced via the Huisgen cycloaddition reaction for improved binding to mineralized tissue. As proof of the design concept, water‐soluble palladium, platinum, silver, gold, and rhodium nanocrystals are synthesized in one step from simple precursors.