Background-No therapy has been shown to improve survival in heart failure (HF) with a normal ejection fraction (EF).There are plausible reasons to hypothesize that statins may be of benefit in HF with a normal EF. Methods and Results-We evaluated 137 patients with HF and an EF Ն0.50. The effect of treatment received at study entry on survival was determined. During a follow-up of 21Ϯ12 months, 20 deaths were observed. Treatment with an ACE inhibitor or receptor blocker, ␤-blocker, or calcium blocker had no significant effect on survival.

With slowed relaxation during the development of HF, E(M) is reduced and delayed so that it occurs after early, rapid filling. Thus, with slowed relaxation, E(M) does not respond to the early diastolic LA to LV pressure gradient, because it occurs when LV pressure is greater than or equal to LA pressure.

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