In this study, TTPN was a good prognostic indicator for PFS beyond TTPN and OS beyond TTPN in metastatic prostate cancer cases after primary ADT. Different TTPNs had different implications for predicting survival beyond TTPN.

Higher PSA nadir was associated with shorter PFS, CSS and OS in Chinese metastatic prostate cancer patients following primary ADT. The survival outcomes may serve as references in deciding the best treatment strategy in Chinese prostate cancer patients.

Cutting sodium intake is considered to ameliorate nocturia and the positive correlation between estimated daily sodium intake and nocturia has been recognized recently in urology clinics. However, this relation can be still controversial to apply to the general population. Here we analyzed this relation cross-sectionally and longitudinally in the Nagahama cohort study.METHODS: The Nagahama cohort study is a population-based health survey in Nagahama city, Japan and comprised of a questionnaire survey, physiological, and biochemical measures of participants aged 30-75 years. The first survey was performed from 2008 to 2010, and the follow-up evaluation was performed after 5 years as the second survey. Among them, a total of 7557 participants of median age 58 years (2593 in male and 4964 in female) with nocturia less than 4 times were analyzed in this study. We excluded participants who did not attend the second survey or with missing data for the analyses. Nocturia was assessed by IPSS Q7 and estimated daily sodium intake was calculated using Tanaka's formula (Tanaka T, et al J Hum Hypertens. 2002, 16: 97-103). The nocturia progression was defined here as equal or more than 2 times increase of nighttime voiding during the 5 years. The associations of estimated daily sodium intake and nocturia were evaluated in multivariate models including baseline characteristics as age, sex, BMI, activity, alcohol and smoking, and clinical variables as diabetes, hyperlipidemia, hypertension, renal insufficiency, depressive symptoms, insomnia and sleep apnea. RESULTS: The cross-sectional analysis showed an inverse correlation between the estimated daily sodium intake and nocturia (defined as nighttime voiding frequency >[1 time) in female participants only (OR 0.966, p[0.025), but this significant relation was not observed in more severe nocturia (nighttime voiding frequency >[2 or >[3). The longitudinal analysis revealed a strong positive correlation between the estimated daily sodium intake and nocturia progression in female participants (OR 1.187, p[0.0003), but not in males.CONCLUSIONS: Careful consideration is required for the relation between estimated daily sodium intake and nocturia in the general population since the inverse correlation was observed in female participants in the cross-sectional study. On the other hand, the positive correlation was obtained between estimated sodium intake and nocturia progression in the longitudinal study, which indicates that there is a specific female group susceptible to high sodium intake in progression of nocturia.

dorsal part of the limbs. Ureteral stents are placed and brought out through the abdominal wall. Anterior plate is finally sutured.RESULTS: Mean age was 64.5 years . Seventeen out of 20 patients were males; 3 were females. One non-surgical intraoperative complication (myocardial infarction requiring an acceleration of operative time) was recorded. During post-op course, two cases of urinary leakage at the neovescical-urethral anastomosis were evident and required prolonged catheterization. Mean length of stay was 17 days (12-27), excluding a single case of prolonged hospitalization due to C. Albicans superinfection. The 30-day readmission rate was 20% (4/20) due to febrile urinary tract infections; 90-day readmission rate was just 5% (1 symptomatic lymphocele requiring percutaneous drainage). Most male patients (14/17) reported daytime continence with insignificant post-voided residual. Between those patients in which nerve-sparing approach was pursued e and have more than 90 days of follow up e 3/5 referred potency. Regarding female patients, incomplete voiding is reported in a case and urinary incontinence (2 pads/day) in another.CONCLUSIONS: Intracorporeal neobladder reconstruction is a complex procedure even for expert robotic surgeons. Nevertheless, the standardization of the surgical approach e as displayed in the video e facilitates a rapid implementation of the procedure with positive surgical and clinical outcomes.