No abstract

Huntington's disease (HD) is a fatal genetic disorder that causes the progressive breakdown of nerve cells in the brain. It deteriorates a person's physical and mental abilities usually during their prime working years and there is no cure. HD is known as the quintessential family disease because every child of a parent with HD has a 50% chance of inheriting the faulty gene. Symptoms usually appear between the ages of 30 to 50, and worsen over a 10-to 25-year period. Ultimately, the weakened individual succumbs to pneumonia, heart failure or other complications. Everyone has the gene that causes HD, but only those that inherit the expansion of the gene will develop HD and perhaps pass it on to each of their children. Every person who inherits the expanded HD gene will eventually develop the disease. Over time, HD affects the individual's ability to reason, walk and speak. Hereby, we describe the case of a 35-year-old patient with HD presenting with cognitive and motor disturbances to underline the diagnostic challenges and differential diagnostic options.

Miller Fisher syndrome is a rare neurological disease that is considered to be a variant of Guillain-Barré syndrome. It is characterized by abnormal muscle coordination (ataxia), paralysis of the eye muscles (ophthalmoplegia), and absence of the tendon reflexes (areflexia). Additional symptoms include generalized muscle weakness and respiratory failure. Symptoms are usually preceded by a viral illness. This paper describes a clinical case of the syndrome in a patient who presented primarily with blurred and double vision, and gait disturbance.

Исхемичните мозъчни инсулти са една от най-честите причини за инвалидизация и смъртност, като заемат между 60 и 85% от всички видове инсулти. Причините могат да бъдат ред заболявания, като най-честите са артериалната хипертония, атеросклерозата, захарният диабет, системни ревматологични заболявания, хематологични заболявания, злоупотреба с вредни вещества и други. В последните години наблюдаваме тенденцията, при която възрастта на болните от исхемични инсулти рязко намалява. Случаят, който представяме, е на 36-годишен мъж със съпътстваща артериална хипертония.