No abstract

In the field of pharmaceutical compound crystallization, one of the challenging tasks is to control the nucleation and the polymorphism. With these objectives, it becomes clear that an important stage is the phase diagram determination of the considered substance. We have investigated the phase diagram of a pharmaceutical compound in a mixture of ethanol/water. We have observed and characterized, in this phase diagram, a solid‐solid (polymorphism) and a liquid‐liquid phase separation as a function of temperature and drug substance concentration.

No abstract

Induction time, a measure of how long one will wait for nucleation to occur, is an important parameter in quantifying nucle-ation kinetics and its underlying mechanisms. Due to the stochastic...