Barber-Say syndrome (BSS) is extremely rare, caused by a genetic mutation in the TWIST2 gene characterized by significant dysmorphology, affecting less than 20 people worldwide. 1 The most common oral complications, described in literature, are taurodontism, macrostomia, and retention of tooth eruption caused by gingival fibromatosis (GF). 1,2 The GF is also a rare condition and characterized by pathological, diffuse, or local gingival overgrowth. This condition may be related to hereditary factors associated with syndromes or as a non-syndromic hereditary gingival fibromatosis, it can also develop as a side effect of anticonvulsants, immunosuppressants, or calcium channel blockers, and it is essential to note that it is not related to intellectual disability. 2Gingival fibromatosis leads to functional, esthetic, and psychological issues, such as partial or total coverage of the dental crowns causing poor positioning and prolonged retention of the teeth. 3 It usually interferes with speech, lip sealing, and chewing, but above all, it can become a psychological burden and affect the patient's self-esteem. 3,4

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