From the findings, CAM shows potential as an alternative to the pig buccal mucosa as an in-vitro buccal model. The robustness of the CAM for drug permeation studies is affected by its age.

The CAM model can be applied to assess pharmaceutical and cosmetic formulations in early development work to gain useful insights to potential irritancy and biological effects of components and formulations.

It was concluded that the LDPI offers a rapid and non-invasive method to measure blood perfusion in the CAM. The latter provides a potentially useful platform in formulation studies to evaluate the effects of additives on drug absorption using caffeine or glyceryl trinitrate as model drugs.