Objective: To correlate hypotension and cerebral saturation from near-infrared spectroscopy (cNIRS) in neonates on dopamine. Study Design: Retrospective review of neonates receiving dopamine between August 2018-2019 was performed. Hypotension thresholds included mean arterial pressure (MAP) of postmenstrual age (PMA) ± 5mmHg, 30mmHg, and gestational age (GA) ± 5mmHg. Time below threshold MAP was compared to time with cerebral hypoxia (cNIRS <55%). Results: Hypotension occurred 6-33% of time on dopamine in 59 cases. Hypotension did not correlate with abnormal cNIRS overall, within PMA subgroups, or by outcomes. Hypotensive periods with MAP<GA had fewer corresponding percent time with abnormal cNIRS events (3.7±1.3%) compared to MAP <PMA (11.9±4.9%, p<0.003) or 30 mm Hg thresholds (12.2±4.7%, p<0.0001). In the most premature infants, mean cNIRS values during hypotension were still within normal range (57±6%). Conclusion: cNIRS may be a more clinically relevant measure than MAP for assessment of neonatal hypotension.