Although intravitreal bevacizumab treatment is effective in inducing regression of ROP, the effect may be transient. Recurrence can occur later in the course than with conventional laser therapy. Late retinal detachment can occur despite early regression. Longterm favorable structural outcome may require extended observation and retreatment. Laser may be a useful treatment for recurrences.

Red reflex testing is an essential component of the neonatal, infant, and child physical examination. This statement, which is a revision of the previous policy statement published in 2002, describes the rationale for testing, the technique used to perform this examination, and the indications for referral to an ophthalmologist experienced in the examination of children.

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