After intravenous injection of glucose, 750 mg/kg, together with a tracer dose of [U-14C] glucose, into fasted, adult white rats, the following percentages of the administered dose were found in whole organs and tissues : 1. after five minutes : skeletal muscle 30.3, skin 28.1, blood 13.1, adipose tissue 10.7, liver 8.9. 2. Forty minutes after injection the corresponding values were: 35.0, 11.1, 5.0, 4.6 and 9.4%. Expired 1~CO~ was negligible after five minutes: after 40 min it comprised 8% of the total dose administered.-After intragastric administration of 1500 mg/kg of glucose given with a tracer dose of [U-14C] glucose under the same experimental conditions, the alimentary tract contained, after 15, 90 and 180 rain, 60.5, 14.8 and 8.4% respectively of the total x4C dose given. At these times the liver contained 2.9, 10.7 and 15.0%; skin contained 7.5, 7.1 and 5.4%; adipose tissue 2.0, 3.8 and 3.5%, and expired 14CO2 0.4, 11.8 and 31.3% respectively. Details of the uptake of ~4C glucose by other organs and tissues are given, and a balance sheet for the injected material is attempted. Contribution de diffgrents organes et tissus du rat d l'assimilation du glucose R~sumd. Aprbs l'injection intraveineuse de glucose (750 mg/kg) en mSme temps qu'une dose traceuse de U-14C-glucose, ~ des rats blancs adultes ~ jeun, los pourcentages suivants de la dose administrde ont dt6 retrouvds dans tousles organes et tissus: 1. aprbs cinq minutes: muscle squelettiquc 30.3, peau 28.1, sang 13.1, tissu adipeux 10.7, foie 8.9.2. Quarante minutes aprbs l'injection, les valeurs correspondantes 6taient los SUlvantes: 35.0, 11.1, 5.0, 4.6 et 9.4%. Le 14CO2 ddgagd dtait ndgligeable apr~s 5 rain: aprbs 40 rain il reprdsentait 8% de la dose totale administrde.-Aprbs l'administration intragastrique de 1500 mg/kg de glucose, donnd en mSme temps qu'une dose traeeuse de U-laC-glucose dans los mSmes conditions expdrimentMes, le tube digestif contenair aubout de 15, 90 et 180 rain, 60.5, 14.8 et 8.4% respectivcment de la dose totale de 140 administrde. A cos moments lk le foie contenait respectivement 2.9, 10.7 et 15.0%; la peau contenait 7.5, 7.1 et 5.4%; le tissu adipeux 2.0, 3.8 et 3.5%, et le laCO2 ddgagd dtait de 0.4, 11.8 et 31.3%. On donne des ddtails sur la captation du 14C-glucose par d'autres organes et tissus, et on essaye de dresser un bilan du produit injectd.

No abstract

A method is described for recording kymographically the systolic contraction and the resting length of the electrically stimulated, isolated right ventricle of the guinea pig. Two samples of Digitalis purpurea leaf and a sample of Digitalis lanata have been assayed in terms of the Third International Standard of D. purpurea using metameters dependent on changes in the systolic contractions and resting length of the muscle and the time elapsing before the changes occur. In a similar manner digitoxin and ouabain have been assayed in terms of digoxin. The results are compared with those obtained by slow intravenous infusion of the preparations into guinea pigs. The potencies derived from the two methods are in close agreement in the case of the digitalis leaf preparations. Digitoxin, however, is more active than digoxin on the ventricle preparation irrespective of the metameter used and less active by the slow infusion method, while ouabain has the same activity as digoxin on the ventricle and twice the activity by the infusion method. The results for ouabain on the ventricle using the different metameters, are homogenous, those for digitoxin are not. There is little difference between the general actions of the three glycosides on the ventricle but each glycoside is capable of producing different effects on systolic contraction and resting length depending on the dose employed. The possible mechanisms responsible for these effects are discussed.