No abstract

Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity and some of these have been documented in association or preceded by oral epithelial dysplasia (OED). Aggressive cancers with fast growth have demonstrated overexpression of some glucose transporters (GLUTs). Thus, the aim of this study was to analyze the immunohistochemical expression of the glucose transporter, GLUT-1, in OEDs and OSCCs, seeking to better elucidate the biological behavior of neoplasias. Fifteen cases were selected this research of both lesions. Five areas were analyzed from each case by counting the percentage of positive cells at 400x magnification. Immunoreactivity of GLUT-1 was observed in 100% of the samples ranging from 54.2% to 86.2% for the OSCC and 73.9% to 97.4% for the OED. Statistical test revealed that there was greater overexpression of GLUT-1 in OED than the OSCC (p=0.01). It is believed the high expression of GLUT-1 may reflect the involvement of GLUT-1 in early stages of oral carcinogenesis.

No abstract

The objective of this case is to discuss the endodontic management in patient diagnosed with Progressive Ossificans Fibrodysplasia (POF) who sought the dental service due to discomfort in the mandible. Minor mobility of the peripheral joints, spinal involvement, gait limitation, inability to sit, report of joint pain, and limitation of TMJ movements were observed on the extra-oral examination. The intraoral examination revealed the presence of ectopic teeth (13 and 23), prolonged retention of primary teeth (53 and 63), dental gyrosurgery (34 and 33), caries lesion on teeth 36 and 47, and dental crowding. To the percussion test and the thermal pulp sensitivity of the tooth 36, there was no response, indicating pulp necrosis. Conventional endodontic therapy was performed under intrapulpal anesthesia and the dental chair placed at 45º. The patient evolved without painful symptomatology, is free of heterotopic ossification resulting from the treatment and her ability to open the mouth remained the same.

O câncer oral geralmente exige tratamento cirúrgico associado ou não à radioterapia e/ou à quimioterapia, acarretando comprometimentos funcionais e estéticos que afetam a qualidade de vida dos pacientes. Portanto, neste estudo, buscou-se analisar as principais evidências sobre a qualidade de vida existentes na literatura científica e apontar quais as principais dimensões da qualidade de vida afetadas em pacientes com câncer de cavidade oral, avaliados pelo Questionário da Universidade de Washington. Para tanto, fez-se uma revisão integrativa da literatura, com as seguintes etapas: adoção da questão norteadora, busca de artigos nas bases Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) e Medical Literature Analysis and Retrieval System Online (MEDLINE), coleta de dados, análise crítica, discussão dos resultados e construção da revisão. Foram selecionados e analisados 16 artigos, sendo que os principais resultados mostraram que: a maioria dos pacientes é do gênero masculino, encontra-se no fim da 6ª década de vida, foi diagnosticada em estágios avançados, tendo mastigação, paladar, deglutição e saliva como principais domínios da qualidade de vida comprometidos. Conclui-se que é necessário considerar tais domínios afetados no planejamento terapêutico desses pacientes, para que os cuidados sejam personalizados e adequados.