The purpose of the study was to assess the prevalence of post-stroke pain and the effectiveness of its diagnosis and treatment in the conditions of university clinic. It was shown that the frequency of post-stroke pain syndrome is 55.8% of the total number of patients with PPS. The pain in the shoulder joint of the paretic limb is most often recorded, due to the subluxation of the humerus, which is recorded in 28.3% of patients with PPS during hospital stay and 20.3% in the first weeks after discharge. The frequency of PPS of the central genesis is 31.1%. Syndrome of complex regional pain occurs in 4.4% of patients, pain associated with spasticity – in 13.0%. The use of visual analog scales makes it possible to diagnose post-stroke pain syndrome in patients who are conscious and have no significant cognitive deficits. With the application of complex treatment of pain syndrome, a satisfactory clinical effect is achieved in all patients, and the best response to treatment was in patients with pain in the shoulder joint of the paretic limb due to the subluxation of the head of the humerus.