SummaryBackground-Metformin might reduce insulin requirement and improve glycaemia in patients with type 1 diabetes, but whether it has cardiovascular benefits is unknown. We aimed to investigate whether metformin treatment (added to titrated insulin therapy) reduced atherosclerosis, as measured by progression of common carotid artery intima-media thickness (cIMT), in adults with type 1 diabetes at increased risk for cardiovascular disease.

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A study of aspirated sternal bone marrow of 50 normal human adult volunteer subjects has been presented. Samples of exactly 3 cc. each were collected in a uniform manner. The technic of performing total nucleated cell counts, differential counts, reticulocyte counts, and megakaryocyte counts has been described and the results given. These results have been subjected to statistical analysis and compared with those of other workers.