OBJECTIVESTo assess the efficacy of mifepristone with misoprostol combination in first trimester abortion. To compare this combination with vaginal misoprostol alone for the first trimester MTP. To compare the various parameters involved in MTP in both the methods and assess the most suitable method for first trimester MTP. METHODSAn interventional prospective study conducted in the Department of Obstetrics and Gynaecology at Government Thoothukudi Medical College, Thoothukudi, during 2013Thoothukudi, during -2015. During this study, 125 patients who attended the family planning clinic requesting first trimester termination of pregnancy were selected based on the inclusion, exclusion criteria. Out of 125 patients, 100 were randomly assigned to vaginal misoprostol group and 25 to mifepristone with misoprostol group. The study was approved by the hospital ethical committee. RESULTSOn analysing both the methods had less induction abortion interval, but 93% of abortions occurred within 4 hours of administration in mifepristone and vaginal misoprostol. CONCLUSIONThus, the combined regimen has more rate of complete abortion with less induction abortion interval than when misoprostol alone was used.