has also been involved in generation of cancer stem cells (CSCs), the subpopulation of cells identified within tumors as having self-renewal, tumor invasion, migration, drug resistance and cancer relapsing capability (Pradella et al. 2017;Siddharth et al. 2017).The drug efflux efficiency of CSCs comes from the increased expression of ATP-binding cassette (ABC) transporters (Dai et al. 2017). Chemo resistance of stem cells is thought to be provided through ABC transporters, and therefore these ABC transporters have been highly studied in stem cells (Chikazawa et al. 2010). EMT is an important regulator of ABC transporters and EMT-related transcription factors play a major role in regulating ABC transporters expression thereby promoting drug resistance in tumor cells (Jiang et al. 2017).The side population (SP) cells are defined by their efflux capability of the fluorescent DNA-binding dye Hoechst 33342 through their ABC transporters and are enriched in stem cells, which has self-renewal capacity and obeyed

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