A highly efficient synthesis of phenanthridine/benzoxazine-fused quinazolinones by ligand-free palladium-catalyzed intramolecular C-H bond activation under mild conditions has been developed. The C-C coupling provides the corresponding N-fused polycyclic heterocycles in good to excellent yields and with wide functional group tolerance.

A rapid and efficient metal‐free synthesis of 3,5‐disubstituted‐1,2,4‐oxadiazoles has been developed via iodine‐induced oxidative cyclisation of N‐acyl amidines. This eco‐friendly approach allows wide functional group tolerance and results in the direct access of highly diversified 1,2,4‐oxadiazoles in 59–94 % yields.

Palladium-Catalyzed Synthesis of Phenanthridine/Benzoxazine-Fused Quinazolinones by Intramolecular C-H Bond Activation. -(GUPTA, P. K.; YADAV, N.; JAISWAL, S.; ASAD, M.; KANT, R.; HAJELA*, K.; Chem. -Eur. J. 21 (2015) 38, 13210-13215, http://dx.doi.org/10.1002/chem.201501591 ; Med. Process Chem. Div., Cent. Drug Res. Inst., Lucknow 226 031, India; Eng.) -M. Paetzel 06-194

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