ABSTRACT… Typhoid fever caused by Salmonella Typhi, is the most common gastrointestinal infectious disease affecting all over the world particularly in Asia where more than 13 millions peoples are affected. Six hundred thousand (600.0000) death occur annually all over the world. Nearly eighty percent (80%) occur in Asia. The main source of infection is contaminated food, water and poor hygiene. Monotherapy, emerging drug resistance and long duration drug treatment is further complicating the problem.2 Approach to combination antibiotic therapy and shortest duration of treatment is needed. Period: January 2016 to June 2016. Objectives: To determine the outcome of combination versus mono anti-biotic therapy in typhoid fever. Study Design: A prospective descriptive study. Place of Study: Mohi-Ud-Din Teaching Hospital Mirpur AJK. Results: Among 138 patients, the relapse rate was high in patients treated with monotherapy as compared combination therapy. Conclusion: Relapse is more common in ciprofloxacin and ceftriaxone groups. Among combination therapy, (ciprofloxacin and ceftriaxone,) relapse was less common. When relapsed patients were retreated with combination therapy, the patients were completely cured. Key words:Salmonella Typhi, Blood Culture, Widal Test, Typhidot, Ciprofloxacin, Ceftriaxone. Article Citation: Nadeem A, Abid S, Abid MH. Typhoid fever; to determine the outcome of combination versus mono anti-biotic therapy in typhoid fever. Professional Med J 2018;25(1):39-44.

Typhoid fever caused by Salmonella Typhi, is the most common gastrointestinalinfectious disease affecting all over the world particularly in Asia where more than 13 millionspeoples are affected. Six hundred thousand (600.0000) death occur annually all over the world.1Nearly eighty percent (80%) occur in Asia. The main source of infection is contaminated food, waterand poor hygiene. Monotherapy, emerging drug resistance and long duration drug treatmentis further complicating the problem.2 Approach to combination antibiotic therapy and shortestduration of treatment is needed. Period: January 2016 to June 2016. Objectives: To determinethe outcome of combination versus mono anti-biotic therapy in typhoid fever. Study Design:A prospective descriptive study. Place of Study: Mohi-Ud-Din Teaching Hospital Mirpur AJK.Results: Among 138 patients, the relapse rate was high in patients treated with monotherapyas compared combination therapy. Conclusion: Relapse is more common in ciprofloxacin andceftriaxone groups. Among combination therapy, (ciprofloxacin and ceftriaxone,) relapse wasless common. When relapsed patients were retreated with combination therapy, the patientswere completely cured.