ABSTACT The Laparoscopic Cholecystectomy (LC) is the gold standard treatment modality for uncomplicated acute or chronic cholecystitis with cholelithiasis. Conventional LC is normally performed with a Monopolar electrocautery which can cause iatrogenic injury of adjacent viscera via thermal side effects The Harmonic scalpel (HS) is an advanced minimally invasive surgical tool with minimal peripheral tissue damage. The main objective of this study is to evaluate the beneficial aspects and disadvantages of Harmonic scalpel compared with Monopolar electrocautery.