The distribution pattern of ten species of Synotis (C.B. Clarke) C. Jeffrey & Y.L. Chen in phytogeographical regions and bio-climatic zones in Nepal along with the species richness was studied. Central Nepal houses the highest number of species, followed by the east Nepal. West Nepal has the least number of species. Within the bio-climatic zones, the highest numbers of species are present in the temperate zone, followed by subalpine zone and then subtropical zone. Alpine zone houses only three species of Synotis. The species richness is peaked in the central Nepal and at the elevation of 2100 -2200 m and 2400 -2600 m.