2005 Multi-membered N-heterocycles R 0690 A Versatile Approach for the Synthesis of 1-Methyl-4H[1,2,4]triazolo[4,3-a][1,4]benzodiazepine N 5 -Oxide. -Title triazolobenzodiazepines (VIII) and the corresponding methyl-substituted N-oxide (XI) are synthesized starting from chloroacetyl isatin (I), using hydrazine to build the triazole ring. -(GUPTA, A.; SIROHI, R.; SHASTRI, S.; KISHORE*, D.; J. Indian Chem.

l,2,3-Benzotriazin-4-(3H)-one(3) and its 6-chloro derivative (4) on thermal condensation with α-amino acids yielded 3H-l,4-benzodiazepin-(lH,4H)-2,5-diones(7-12) in moderate to good yield. The cyclocondensation is believed to proceed through the formation of an iminoketene intermediate (5).

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The title compounds (VIII) are synthesized via intramolecular cyclization from precursors (VI) in good yields. Compounds (VI) are synthesized by two different methods, but with similar yields. -(SIROHI, R.; SINGH, A.; SHASTRI, S.; KISHORE*, D.; J. Indian Chem.

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