Synthesis of Ni(II) and Fe(III) complexes with Schiff base 6-methyl-3-((quinolin-3-ylimno) methyl)-4H-chromen-4-one obtained from 3-formyl-6methylchromone and 3-aminoquinoline.Schiff base and its complexes were characterized by analytical data, elemental analysis, molar conductance, thermogravimetric analysis. The structural investigation performed by UV-Vis, IR and 1 HNMR spectral techniques. Interpretation of elemental analysis shown 2:1 molar ratio of Schiff base with metal complexes. Molar conductance values indicate neutral nature of metal complexes. Antimicrobial activity studied at different concentration (MIC method) by disc diffusion technique. Schiff base and the metal complexes found to be significant antibacterial and antifungal agents.