BACKGROUND The aim of the study is to study the most common organisms encountered and their sensitivity and resistance to antibiotics in postoperative wound infection and to study relation of emergency and elective surgery to postoperative wound infection and to study efficacy of different modes of preoperative preparation on postoperative wound infection and to study distribution of postoperative wound infection among different surgeries based on bacterial contamination such as clean, clean-contaminated, contaminated and dirty. MATERIALS AND METHODS Seventy five cases of postoperative wound infection were analysed. Appropriate history and examination was done. Culture and sensitivity reports were reviewed. RESULTS Most common organism encountered is E. coli (32%), most sensitive antibiotic is amikacin (69.3%) and most resistant antibiotics are cephalexin (73.3%) and erythromycin (73.3%). Postoperative wound infection was commonly encountered in emergency cases (69.3%) and dirty type of cases (62.7%). Postoperative infection is most commonly found in patients prepared by shaving (76%) in >24 hours before surgery (64.0%) and patients not taken preoperative bath (77.3%). CONCLUSION Most common organism in postoperative wound infection is E. coli. Most sensitive antibiotic is amikacin and most resistant antibiotics are cephalexin and erythromycin. Postoperative wound infection is more in emergency case, dirty type of cases and patients prepared by shaving in >24 hours before surgery and who have not taken bath.