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The interaction of a cyanonitrosyl-manganate complex with DNA has been studied by u.v.-vis spectroscopy, circular dichroism, fluorescence and gel electrophoresis techniques. As the DNA 260 nm band remained insensitive to interaction, the interaction ratio was determined by monitoring the CN ) fi Mn LMCT band observed at 222 nm, and the interaction ratio was found to be in the complex (D): DNA (P) ¼ 1:0.30 from the spectrophotometric titration. The above-mentioned physical measurements indicate that the binding mode is not intercalative and the cyanonitrosyl system is a groove binder.

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