Background: Carcinoma breast is the leading cause of death in female. It is difficult to access clinically whether the lump is benign or malignant. Fine needle aspiration cytology, Tru-cut needle biopsy, Imprint cytology were performed on 64 patients and their findings are compared with histopathological examination and tried to evaluate the accuracy and usefulness of these methods. Methods: This study was conducted at SCB Medical College, CTC in Surgery Dept. from Oct 2014 to Sept.2016 in both male and female patients. The diagnostic accuracy of the methods were accessed and compared. Results: Out of 64 cases studied 35 cases are benign and 29 cases are malignant. Sensitivity and specificity of FNAC is 93.33% and 97.05% respectively. Similarly sensitivity and specificity of TCNB and Imprint Cytology are 100%, 100% and 96.42%, 100% respectively. Accuracy of FNAC, TCNB, IC are 95.31%, 98.43%, 95.31% respectively. Conclusion: This study shows the correct diagnosis by FNAC, TCNB, IC is 93.33%, 100%, 96.42% respectively in comparison with HP study. So if FNAC gives correct diagnosis, we can go for definite surgery but if FNAC is suspicious then plan for TCNB and intraoperative IC was done to correlate the finding and definite surgery was planned.